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- September 3, 2010 |
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CME on Diabetes is a website built to transmit top-level CME conferences given by international experts in endocrinology, insulin resistance, prediabetes, metabolic syndrome and type 2 diabetes. More than 2.6 million slides have been viewed since the website launch. Thank you for your continued support and commitment!
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"Calcium & Metabolic Bone Disorders"Dr. Andrew Karaplis (biography)
English - 2003-08-10 - 54 minutes
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Summary :
The World Health organization has named this decade the “Bone and Joint Decade”, in anticipation of new methods of prevention and treatment of musculoskeletal disorders.
The past decade has provided us with much new information on calcium homeostasis. Identification of the PTh receptor and its mutations have now been linked to a number of disorders for which there were no previous explanations, for example Jansen Type Metaphyseal Chondrodysplasia. New discoveries about the calcium sensing receptor mutations have led to the development of calcimimetic drugs, which potentiate the activity of calcium and will be available soon. Various genetic studies have emerged in the past decade giving insights into the origin of diseases such as hypophosphatemic rickets and others. An in-depth update on osteoporosis and other bone diseases is also given.
Learning objectives :
The participant will get an overview of the last decade’s important discoveries in the research of calcium and metabolic bone disorders.
Bibliographic references :
Kos CH, Karaplis AC, Peng JB, Hediger MA, Goltzman D, Mohammad KS, Guise TA, Pollak MR. The calcium-sensing receptor is required for normal calcium homeostasis independent of parathyroid hormone. J Clin Invest. 2003 Apr;111(7):1021-8.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi
Chan GK, Miao D, Deckelbaum R, Bolivar I, Karaplis A, Goltzman D. Parathyroid Hormone Related Peptide Interacts with Bone Morphogenetic Protein 2 to increase Osteoblastogenesis and decrease Adipogenesis in Pluripotent C3H10T1/2 Mesenchymal Cells. Endocrinology. 2003 Aug 28 [Epub ahead of print].
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi
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