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- December 1, 2008 |
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CME on Diabetes is a website built to transmit top-level CME conferences given by international experts in endocrinology, insulin resistance, prediabetes, metabolic syndrome and type 2 diabetes. More than 2.6 million slides have been viewed since the website launch. Thank you for your continued support and commitment!
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| Presentation |
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"Glycaemic Efficacy of Glitazones"Dr. Sophia Zoungas (biography)
English - 2007-11-10 - 31 minutes
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 | (42 slides) |
Summary :
In this presentation Dr. Zoungas discusses the efficacy of glitazone monotherapy. She introduces the ADOPT study which compares the efficacy of three different monotherapies, including a glitazone (1).
In the UKPDS over time, it was shown that treatment with metformin or sulphonylurea becomes less efficient (2). Dr. Zoungas talks about the current management of type 2 diabetes (3), and the delays that often occur between stepping up from monotherapy to combination therapy.
The ADOPT study showed promising results for the glitazone, but as Dr. Zoungas points out, there are still some safety concerns to be investigated.
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Learning objectives :
After viewing this presentation the participant will be able to discuss:
- The current management of type 2 diabetes and its effectiveness
- The ADOPT study on the efficacy of glitazone monotherapy
- Safety of glitazones
Bibliographic references :
1- Kahn SE, Haffner SM, Heise MA, Herman WH, Holman RR, Jones NP, Kravitz BG, Lachin JM, O'Neill MC, Zinman B, Viberti G; ADOPT Study Group.Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy. N Engl J Med. 2006 Dec 7;355(23):2427-43.
2- Turner RC, Cull CA, Frighi V, Holman RR.Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group. JAMA. 1999 Jun 2;281(21):2005-12.
3- Kobayashi M.Effects of current therapeutic interventions on insulin resistance. Diabetes Obes Metab. 1999 May;1 Suppl 1:S32-40. Review.
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