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- December 1, 2008 |
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"Interleukin-6 Family Cytokines: A Link Between Exercise and Enhanced Insulin Sensitivity?"Dr. Mark Febbraio (biography)
English - 2006-05-06 - 30 minutes
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Summary :
In this presentation, Dr. Febbraio shares some new information about interleukin-6 (IL-6), and ciliary neurotrophic factor (CNTF), a member of the IL-6 family.
IL-6 is elevated in the plasma of obese persons and has been thought to be a mediator of insulin resistance. There is however some evidence to suggest that IL-6 is not related to insulin responsiveness (1), and further, human skeletal myocytes have been found to produce IL-6 during exercise (2). Dr. Febbraio shows some other data indicating a role of IL-6 to increase insulin sensitivity and fat oxidation in an AMPK dependent manner.
CNTF, a "leptin-like" neurogenic factor, was previously reported in JAMA to induce weight loss in humans (3), and in a study recently published in Nature Medicine it was shown to reverse obesity-induced insulin resistance by activating skeletal muscle AMPK (4). Dr. Febbraio discusses these data and the potential clinical implications.
Copyright © 2006 E-MedHosting.com Inc.
Learning objectives :
After viewing this presentation, the participant will be able to discuss:
- Evidence of production of IL-6 by skeletal myocytes during contraction;
- Effects of IL-6 and CNTF on AMPK activity, lipid metabolism and insulin sensitivity.
Bibliographic references :
1. Carey,A. L., Bruce,C. R., Sacchetti,M., Anderson,M. J., Olsen,D. B., Saltin,B., Hawley,J. A., Febbraio,M. A.Interleukin-6 and tumor necrosis factor-a are not increased in patients with Type 2 diabetes: evidence that plasma interleukin-6 is related to fat mass and not insulin responsiveness Diabetologia, 47, 6, 6/17/2004, Pages 1029-1037.
2. Natalie Hiscock, M. H. Stanley Chan, Teresa Bisucci, Ian A. Darby, and Mark A. FebbraioSkeletal myocytes are a source of interleukin-6 mRNA expression and protein release during contraction: evidence of fiber type specificity FASEB J. 2004 Jun;18(9):992-4.
3. Mark P. Ettinger, MD; Thomas W. Littlejohn, MD; Sherwyn L. Schwartz, MD; Stuart R. Weiss, MD; Harris H. McIlwain, MD; Steven B. Heymsfield, MD; George A. Bray, MD; William G. Roberts, MD; Eugene R. Heyman, PhD; Nancy Stambler, MS; Stanley Heshka, PhD; Catherine Vicary, BS; Hans-Peter Guler, MD Recombinant Variant of Ciliary Neurotrophic Factor for Weight Loss in Obese Adults JAMA. 2003 Apr 9;289(14):1826-32.
4. Watt MJ, Dzamko N, Thomas WG, Rose-John S, Ernst M, Carling D, Kemp BE, Febbraio
MA, Steinberg GR.CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK Nat Med. 2006 May;12(5):541-8.
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