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- December 1, 2008 |
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CME on Diabetes is a website built to transmit top-level CME conferences given by international experts in endocrinology, insulin resistance, prediabetes, metabolic syndrome and type 2 diabetes. More than 2.6 million slides have been viewed since the website launch. Thank you for your continued support and commitment!
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"Lifestyle modification - What does it achieve?"Prof. John Prins (biography)
English - 2008-05-17 - 39 minutes
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Summary :
Does lifestyle modification have proven benefits?
Obesity is associated with increased risk for diabetes and coronary heart disease, and even a ten percent weight loss is associated with decreased mortality, diabetes risk, blood pressure and lipids. These improvements have been summarized in a publication by Jung et al. (1).
In diabetic patients, lifestyle intervention/weight loss can lead to improvement in insulin sensitivity, reduced requirement for medication, a delay in insulin requirement, and better glycaemic control. Lifestyle intervention was also shown to have significant benefits in patients with renal disease, and to reduce liver fat.
There is qualitative research data to show that sexual function improves with lifestyle intervention, and in patients with polycystic ovary syndrome it has been well documented that there are improvements in insulin resistance, ovulation and fertility.
The U.S. Women's Health Study showed that in women who had a ten kilo intentional weight loss there was a thirty percent reduced risk of breast cancer, and similar findings for colon cancer. Other studies are ongoing.
The prevention of osteoporosis has been shown with lifestyle intervention, particularly with exercise, however there is a lack of human data on treating osteoporosis with exercise.
A mechanism which may contribute to the increased atherogenic risk in obesity is the more prolonged and greater oxidative and inflammatory stress seen in obese individuals after ingestion of high-fat, high-carbohydrate meals (2). Also of interest is that a reversion of abnormal adipokine production is seen with weight loss. Prof. Prins concludes that the evidence shows that lifestyle modification is clearly of benefit for patients.
Copyright © 2008 E-MedHosting.com Inc.
Learning objectives :
After viewing this presentation the participant will be able to discuss:
- Obesity-associated health risks
- Clinical benefits of weight loss
- Effects of lifestyle intervention in diabetic patients
- Weight loss and cancer risk (Women's Health Study)
- Exercise and osteoporosis risk
- Proatherogenic mechanisms in obesity
Bibliographic references :
1. Roland T Jung. Obesity as a disease British Medical Bulletin 53:307-321 (1997).
2. Chinmay Patel, Husam Ghanim, Shreyas Ravishankar, Chang Ling Sia, Prabhakar Viswanathan, Priya Mohanty and Paresh Dandona. Prolonged Reactive Oxygen Species Generation and Nuclear Factor-{kappa}B Activation after a High-Fat, High-Carbohydrate Meal in the Obese J Clin Endocrinol Metab. 2007 Nov;92(11):4476-9.
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