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- December 1, 2008 |
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"Lipids, Insulin Resistance and AMPK"Prof. Edward W. Kraegen (biography)
English - 2004-06-07 - 52 minutes
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Summary :
In this presentation Dr. Kraegen discusses how lipids generate insulin resistance in muscle and liver, and whether activation of the AMP-activated protein kinase (AMPK) pathway is an option in treating insulin resistance.
Factors such as visceral adiposity and adipokine action correlate with insulin resistance, as does the accumulation of lipids in non-adipose tissue which will be discussed here. AMPK activators such as rosiglitazone and metformin improve insulin sensitivity, and have varying effects in muscle and liver.
Copyright © 2004 E-MedHosting.com Inc.
Learning objectives :
After viewing this presentation the participant will be able to discuss the following:
- How lipids generate insulin resistance in muscle and liver
- Whether activation of the AMPK pathway is an option in treating insulin resistance
Bibliographic references :
EW Kraegen, PW Clark, AB Jenkins, EA Daley, DJ Chisholm and LH StorlienDevelopment of muscle insulin resistance after liver insulin resistance in high-fat-fed rats Diabetes. 40:1397-1403.
L.H. Storlien, D. E. James, K. M. Burleigh, D. J. Chisholm and E. W. KraegenFat feeding causes widespread in vivo insulin resistance, decreased energy expenditure, and obesity in rats Am J Physiol. 251:E576-E583.
LH Storlien, AB Jenkins, DJ Chisholm, WS Pascoe, S Khouri and EW KraegenInfluence of dietary fat composition on development of insulin resistance in rats. Relationship to muscle triglyceride and omega-3 fatty acids in muscle phospholipid Diabetes 40:280-289.
EW Kraegen, PW Clark, AB Jenkins, EA Daley, DJ Chisholm and LH StorlienDevelopment of muscle insulin resistance after liver insulin resistance in high-fat-fed rats Diabetes 40:1397-1403.
Gan SK, Samaras K, Thompson CH, Kraegen EW, Carr A, Cooper DA, Chisholm DJ.Altered myocellular and abdominal fat partitioning predict disturbance in insulin action in HIV protease inhibitor-related lipodystrophy. Diabetes. 2002 Nov;51(11):3163-9.
ME Griffin, MJ Marcucci, GW Cline, K Bell, N Barucci, D Lee, LJ Goodyear, EW Kraegen, MF White, and GI ShulmanFree fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade/ Diabetes 48: 1270-1274.
Chunli Yu, Yan Chen, Gary W. Cline, Dongyan Zhang, Haihong Zong, Yanlin Wang, Raynald Bergeron, Jason K. Kim, Samuel W. Cushman, Gregory J. Cooney, Bronwyn Atcheson, Morris F. White, Edward W. Kraegen, and Gerald I. Shulman Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle/ J. Biol. Chem., Dec 2002; 277: 50230 – 50236.
Kraegen EW, James DE, Storlien LH, Burleigh KM, Chisholm DJ. In vivo insulin resistance in individual peripheral tissues of the high fat fed rat: assessment by euglycaemic clamp plus deoxyglucose administration./Diabetologia. 1986 Mar;29(3):192-8.
Kusunoki M, Storlien LH, MacDessi J, Oakes ND, Kennedy C, Chisholm DJ, Kraegen EW.Muscle glucose uptake during and after exercise is normal in insulin-resistant rats. Am J Physiol. 1993 Feb;264(2 Pt 1):E167-72.
Iglesias MA, Ye JM, Frangioudakis G, Saha AK, Tomas E, Ruderman NB, Cooney GJ, Kraegen EW.AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats. Diabetes. 2002 Oct;51(10):2886-94.
Miguel A. Iglesias, Stuart M. Furler, Gregory J. Cooney, Edward W. Kraegen, and Ji-Ming YeAMP-Activated Protein Kinase Activation by AICAR Increases Both Muscle Fatty Acid and Glucose Uptake in White Muscle of Insulin-Resistant Rats In Vivo Diabetes 53:1649-1654, 2004.
Fryer LG, Parbu-Patel A, Carling D.The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways. J Biol Chem. 2002 Jul 12;277(28):25226-32.
Zhou G, Myers R, Li Y, Chen Y, Shen X, Fenyk-Melody J, Wu M, Ventre J, Doebber T, Fujii N, Musi N, Hirshman MF, Goodyear LJ, Moller DE.Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest. 2001 Oct;108(8):1167-74.
Ji-Ming Ye, Georgia Frangioudakis, Miguel A. Iglesias, Stuart M. Furler, Bronwyn Ellis, Nicholas Dzamko, Gregory J. Cooney and Edward W. KraegenPrior Thiazolidinedione Treatment Preserves Insulin Sensitivity in Normal Rats during Acute Fatty Acid Elevation: Role of the Liver Endocrinology Vol. 143, No. 12 4527-4535.
Saha AK, Avilucea PR, Ye JM, Assifi MM, Kraegen EW, Ruderman NB.
Pioglitazone treatment activates AMP-activated protein kinase in rat liver and adipose tissue in vivo. Biochem Biophys Res Commun. 2004 Feb 6;314(2):580-5.
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