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- December 1, 2008 |
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"Mechanism and Consequences of Fat-induced Gluconeogenesis"Prof. Joseph Proietto (biography)
English - 2004-06-26 - 28 minutes
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Summary :
In this presentation Prof. Proietto presents data from experimental studies showing the mechanism of fat-induced gluconeogenesis, and the consequences of chronically elevated gluconeogenesis.
Studies done by Prof. Proietto's group showed that rats who were fed a high fat diet exhibited increases in endogenous glucose production, alanine gluconeogenesis and fructose-1,6-bisphosphatase (FBPase) protein levels, and these increases were all lowered by metformin, an inhibitor of gluconeogenesis.
A correlation was found between the rate of alanine gluconeogenesis and levels of FBPase protein, indicating that the high fat diet stimulated an increase in alanine gluconeogenesis via an increase in FBPase levels.
The consequences of chronically increased gluconeogenesis were studied using rats engineered with a non-insulin-responsive phosphoenolpyruvate carboxykinase (PEPCK) transgene. These animals developed metabolic abnormalities such as mild hyperglycemia, insulin resistance, weight gain and dyslipidemia, supporting a role of insulin resistance in the development of these disorders.
Copyright © 2004 E-MedHosting.com Inc.
Learning objectives :
After viewing this presentation, the participant will be able to discuss:
- The mechanism of fat-induced gluconeogenesis involving the up-regulation of fructose-1,6-bisphosphatase protein levels
- The development of specific metabolic abnormalities in an animal model of chronically increased gluconeogenesis
Bibliographic references :
Shaoming Song, Sofianos Andrikopoulos, Christine Filippis, Anne W. Thorburn, David Khan, and Joseph Proietto. Mechanism of fat-induced hepatic gluconeogenesis: effect of metformin Am J Physiol Endocrinol Metab 2001; 281: E275-E282.
A. W. Thorburn, M. E. Baldwin, G. Rosella, J. D. Zajac, S. Fabris, S. Song, J. Proietto. Features of syndrome X develop in transgenic rats expressing a non-insulin responsive phosphoenolpyruvate carboxykinase gene
Diabetologia 1999; 42(4):419 - 426.
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