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- December 1, 2008 |
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"Obesity and Type 2 Diabetes: Impact of Major Weight Loss"Prof. Paul O'Brien (biography)
English - 2005-12-07 - 29 minutes
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 | (27 slides) |
Summary :
In this presentation Prof. O'Brien talks about the effects of major weight loss in type 2 diabetes.
A direct relationship exists between BMI and the risk of developing type 2 diabetes (1,2). Obesity promotes insulin resistance, hyperinsulinaemia and eventual beta-cell failure, so can weight loss “cure” diabetes before beta-cell failure has occurred?
For severely obese individuals in whom conventional weight loss programs are not expected to achieve sufficient weight reduction, the Lap-Band surgical procedure presents a safe and effective option. Prof. O'Brien talks about his experience having treated over 1800 patients with the procedure.
In severely obese type 2 diabetic patients, Lap-Band surgery has been associated with significant metabolic improvements and even remission of diabetes in some patients (3). Prof. O'Brien describes the beneficial changes in insulin sensitivity and beta-cell function seen one year after the operation (4), and introduces an ongoing randomized controlled trial in type 2 diabetic patients, comparing the effects of optimal care with or without Lap-Banding.
Copyright © 2006 E-MedHosting.com Inc.
Learning objectives :
After viewing this presentation the participant will be able to discuss:
- BMI as a risk factor for type 2 diabetes
- Efficacy of conventional weight loss programs
- Benefits of Lap-Band surgery in severely obese type 2 diabetic patients
Bibliographic references :
1. JM Chan, EB Rimm, GA Colditz, MJ Stampfer and WC Willett. Obesity, fat distribution, and weight gain as risk factors for clinical diabetes in men Diabetes Care. 1994 Sep;17(9):961-9.
2. Graham A. Colditz; Walter C. Willett; Andrea Rotnitzky; and JoAnn E. Manson Weight Gain as a Risk Factor for Clinical Diabetes Mellitus in Women Ann Intern Med. 1995 Apr 1;122(7):481-6.
3. John B. Dixon, MBBS and Paul E. O’Brien, MDHealth Outcomes of Severely Obese Type 2 Diabetic Subjects 1 Year After Laparoscopic Adjustable Gastric Banding Diabetes Care 25:358-363, 2002.
4. J. B. Dixon, A. F. Dixon and P. E. O'BrienImprovements in insulin sensitivity and β-cell function (HOMA) with weight loss in the severely obese Diabetic Medicine 20 (2), 127-134.
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