 |
|
 |
- December 1, 2008 |
|
|
Welcome to the #1 online source of information for Diabetes Specialists! An international online community of more than 10,000 Diabetes Specialists.
CME on Diabetes is a website built to transmit top-level CME conferences given by international experts in endocrinology, insulin resistance, prediabetes, metabolic syndrome and type 2 diabetes. More than 2.6 million slides have been viewed since the website launch. Thank you for your continued support and commitment!
|
|
|
| Presentation |
|
"Oxidative Stress: A Common Atherogenic Factor in IR, DM and CVD"Prof. Antonio Ceriello (biography)
English - 2005-04-15 - 30 minutes
|
 | (23 slides) |
Summary :
Type 2 diabetes is a worldwide increasing disease, resulting from the interaction between a subject's genetic makeup and lifestyle. In genetically predisposed subjects the combination of excess caloric intake and reduced physical activity induces a state of insulin resistance. When beta-cells are no more able to compensate for insulin resistance by adequately increasing insulin production, impaired glucose tolerance appears, characterized by excessive post-prandial hyperglycemia. Impaired glucose tolerance may evolve into overt diabetes. All of these three conditions, i.e. insulin resistance, impaired glucose tolerance and overt diabetes are associated with an increased risk of cardiovascular disease. Since all these conditions are also accompanied by the presence of an oxidative stress, this article proposes oxidative stress as the pathogenic mechanism linking insulin resistance with dysfunction of both beta cells and endothelium, eventually leading to overt diabetes and cardiovascular disease. This hypothesis, moreover, may also contribute to explain why treating cardiovascular risk with drugs such as calcium channel blockers, ACE inhibitors, AT-1 receptor antagonists and statins, all compounds showing intracellular preventive antioxidant activity, the onset of new cases of diabetes may also be reduced.
Learning objectives :
After viewing this presentation, participants will be able to discuss:
- The role of Glucose and fatty acid concentration on oxidative stress;
- Oxidative stress in smooth muscle, endothelial, and beta cells;
- The role of oxidative stress on post prandial hyperglycemia, diabetes, metabolic syndrome, and cardiovascular disease.
Bibliographic references :
T Inoguchi, P Li, F Umeda, HY Yu, M Kakimoto, M Imamura, T Aoki, T Etoh, T Hashimoto, M Naruse, H Sano, H Utsumi, and H Nawata High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells Diabetes 2000(49): 1939-1945.
Joseph L. Evans, Ira D. Goldfine, Betty A. Maddux, and Gerold M. Grodsky Are Oxidative Stress-Activated Signaling Pathways Mediators of Insulin Resistance and ß-Cell Dysfunction? Diabetes 2003 (52): 1-8.
Betty A. Maddux, Wendy See, John C. Lawrence, Jr., Amy L. Goldfine, Ira D. Goldfine, and Joseph L. Evans Protection Against Oxidative Stress—Induced Insulin Resistance in Rat L6 Muscle Cells by Micromolar Concentrations of -Lipoic Acid Diabetes 2001 (50): 404-410.
R. Marfella, G. Verrazzo, R. Acampora, C. La Marca, R. Giunta, C. Lucarelli, G. Paolisso, A. Ceriello, and D. Giugliano Glutathione reverses systemic hemodynamic changes induced by acute hyperglycemia in healthy subjects Am J Physiol Endocrinol Metab, Jun 1995; 268: 1167 - 1173
Johannes Pleiner, Georg Schaller, Friedrich Mittermayer, Michaela Bayerle-Eder, Michael Roden, and Michael Wolzt FFA-Induced Endothelial Dysfunction Can Be Corrected by Vitamin C J. Clin. Endocrinol. Metab., Jun 2002; 87: 2913 - 2917.
Krauss S, Zhang CY, Scorrano L, Dalgaard LT, St-Pierre J, Grey ST, Lowell BB. Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction J Clin Invest. 2003 Dec;112(12):1831-42.
Antonio Ceriello and Enrico Motz Is Oxidative Stress the Pathogenic Mechanism Underlying Insulin Resistance, Diabetes, and Cardiovascular Disease? The Common Soil Hypothesis Revisited Arterioscler Thromb Vasc Biol 2004 24: 816 - 823
|
|
|
|
|
|
| Search our website |
 |
| |
Would you like to know more about insulin resistance? Are you looking for information pertaining to Type 2 Diabetes? You can find what you are looking for in over 2000 references available on CMEonDiabetes. |
| |
|
|
| Social |
|
| |
Let others know about this presentation.
|
|
|
|
