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- December 1, 2008 |
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"Oxidative Stress and HDL Dysfunction in Metabolic Syndrome"Prof. John Chapman (biography)
English - 2005-04-15 - 31 minutes
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 | (21 slides) |
Summary :
An atherogenic disequilibrium of lipid metabolism is one of the key features of both the metabolic syndrome (MetS) and type 2 diabetes (DM2). Prof. John Chapman reviews here the disturbed lipid metabolism of the MetS and DM2 and discusses the mechanisms of lipid-induced vascular inflammation.
In particular, the antioxidative properties of HDL cholesterol are discussed along with the components of the HDL molecule that are implicated in its intrinsic anti-atherogenic activity. In addition, Prof. Chapman reviews his own groups research, examining the role that a perturbed HDL metabolism plays in the antioxidative potential of both insulin resistant and MetS patients and the usefulness of 8-isoprostane levels as a marker of attenuated HDL anti-atherogenic activity in these patients.
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Learning objectives :
After viewing this presentation, participants will be able to discuss:
• The three intra-plaque processes involved in plaque rupture
• The five disequilibria that favour the progression of atherosclerosis
• The atherogenic lipid disequilibrium of the metabolic syndrome and type 2 diabetes
• The role of bioactive oxidized lipids in the induction of vascular wall inflammation
• The anti-atherogenic actions of HDL cholesterol
• The components of HDL that are implicated in its intrinsic antioxidative activity
• The usefulness of 8-isoprostanes as a global marker of systemic oxidative stress in the metabolic syndrome.
Bibliographic references :
Kontush A, Chantepie S, Chapman MJ. Small, dense HDL particles exert potent protection of atherogenic LDL against oxidative stress. Arterioscler Thromb Vasc Biol. 2003 Oct 1;23(10):1881-8.
Kontush A, de Faria EC, Chantepie S, Chapman MJ. Antioxidative activity of HDL particle subspecies is impaired in hyperalphalipoproteinemia: relevance of enzymatic and physicochemical properties. Arterioscler Thromb Vasc Biol. 2004 Mar;24(3):526-33.
Chapman MJ. Fibrates in 2003: therapeutic action in atherogenic dyslipidaemia and future perspectives. Atherosclerosis. 2003 Nov;171(1):1-13.
Hansel B, Giral P, Nobecourt E, Chantepie S, Bruckert E, Chapman MJ, Kontush A. Metabolic syndrome is associated with elevated oxidative stress and dysfunctional dense high-density lipoprotein particles displaying impaired antioxidative activity. J Clin Endocrinol Metab. 2004 Oct;89(10):4963-71.
Nobecourt E, Jacqueminet S, Hansel B, Chantepie S, Grimaldi A, Chapman MJ, Kontush A. Defective antioxidative activity of small dense HDL3 particles in type 2 diabetes: relationship to elevated oxidative stress and hyperglycaemia. Diabetologia. 2005 Mar;48(3):529-38
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