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- December 1, 2008 |
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"Panel Discussion: Insulin Resistance Versus Insulin Secretion: The Pathophysiology"Dr. Stuart A Ross (biography)
English - 2002-04-27 - 27 minutes
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Summary :
Panel Discussion: Insulin Resistance Versus Insulin Secretion: The Pathophysiology
Moderator: Stuart Ross, MB
Participants:
Steve Kahn (MD), Daniel Porte Jr (MD) This Panel discussion was held at Lake Louise (Alberta) on April 27th, 2002, Chateau Lake Louise
Learning objectives :
Discussion on the pathophysiology and genetics of the metabolic syndrome, insulin resistance, insulin sensitivity, the "pre-diabetic" state, fat distribution; and the roles of molecules such as resistin and adiponectin.
Bibliographic references :
Adiponectin is not altered with exercise training despite enhanced insulin action.
Hulver MW, Zheng D, Tanner CJ, Houmard JA, Kraus WE, Slentz CA, Sinha MK, Pories WJ, MacDonald KG, Dohm GL.
Department of Physiology, East Carolina University, Greenville North Carolina 27858, USA. hulverm@mail.ecu.edu
Adiponectin is an adipocytokine that is hypothesized to be involved in the regulation of insulin action. The purpose of the present investigation was to determine whether plasma adiponectin is altered in conjunction with enhanced insulin action with exercise training. An insulin sensitivity index (S(I)) and fasting levels of glucose, insulin, and adiponectin were assessed before and after 6 mo of exercise training (4 days/wk for approximately 45 min at 65-80% peak O(2) consumption) with no loss of body mass (PRE, 91.9 +/- 3.8 kg vs. POST, 91.6 +/- 3.9 kg) or fat mass (PRE, 26.5 +/- 1.8 kg vs. POST, 26.7 +/- 2.2 kg). Insulin action significantly (P < 0.05) improved with exercise training (S(I) +98%); however, plasma adiponectin concentration did not change (PRE, 6.3 +/- 1.5 microg/ml vs. POST, 6.6 +/- 1.8 microg/ml). In contrast, in a separate group of subjects examined before and after weight loss, there was a substantial increase in adiponectin (+281%), which was accompanied by enhanced insulin action (S(I), +432%). These data suggest that adiponectin is not a contributory factor to the exercise-related improvements in insulin sensitivity.
Am J Physiol Endocrinol Metab 2002 Oct;283(4):E861-5
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