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- December 1, 2008 |
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"Physical Inactivity and All-Cause Mortality in Australians with 'Undiagnosed' Impaired Glucose Metabolism. The AusDiab Study"Dr. David Dunstan (biography)
English - 2006-09-15 - 24 minutes
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Summary :
Background and Aims: Physical inactivity has been associated with increased all-cause mortality in the general population and in people with type 2 diabetes. However, little is known about the association of physical inactivity among people with ‘undiagnosed’ impaired glucose metabolism. The aim of this study was to examine the association between physical inactivity and all-cause mortality in Australian adults with impaired glucose metabolism.
Materials and Methods: The Australian Diabetes, Obesity and Lifestyle Study (AusDiab) is a nationally representative population-based survey of adults aged ≥ 25 years. Baseline measurements were obtained between 1999 and 2000. Based on an OGTT, 2,471 individuals (1,238 men, 1,233 women) were identified as having impaired glucose metabolism (impaired fasting glycemia [IFG], impaired glucose tolerance [IGT], or undiagnosed type 2 diabetes) at baseline. Self-reported leisure-time physical activity status (physically inactive (0 mins/week) or physically active) was determined using interviewer-administered questionnaires. Potential confounders measured at baseline included: education, smoking status, diseases present at baseline (prior cardiovascular disease, hypertension, dyslipidaemia), waist circumference and television viewing time. Vital status was ascertained in 2005 from the National Death Index.
Results: Over a median follow-up of 5.2 years there were 131 deaths in those identified as having impaired glucose metabolism at baseline. Collectively, in those with impaired glucose metabolism, the age- and sex-adjusted odds ratio (OR) of all-cause mortality associated with being physically inactive was 2.10 (95% CI 1.40-3.15), which remained significant after adjustment for confounders - OR: 1.95 (95% CI 1.28-2.95). Among those with IGT and undiagnosed type 2 diabetes the odds ratios (adjusted for all confounders) of all-cause mortality associated with physical inactivity were 2.26 (95% CI 1.25-4.1) and 2.56 (95% CI 1.12-5.86) respectively. There was no association observed between all-cause mortality and physical inactivity in those with IFG - OR: 1.68 (95% CI 0.53-5.31).
Conclusion: These findings show that physically inactive adults with ‘undiagnosed’ impaired glucose metabolism have more than a two-fold increased risk of all-cause mortality over 5 years. These results further reinforce the importance of promoting physical activity in people with impaired glucose metabolism.
Learning objectives :
After viewing this presentation, the participant will be able to discuss:
- Factors that influence physical inactivity in the population
- Physical activity participation levels in Australian adults
- Effects of physical inactivity on risk of all-cause mortality in people with impaired glucose metabolism
- The importance of promoting active living in people at risk of developing diabetes and cardiovascular disease
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