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- December 1, 2008 |
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Welcome to the #1 online source of information for Diabetes Specialists! An international online community of more than 10,000 Diabetes Specialists.
CME on Diabetes is a website built to transmit top-level CME conferences given by international experts in endocrinology, insulin resistance, prediabetes, metabolic syndrome and type 2 diabetes. More than 2.6 million slides have been viewed since the website launch. Thank you for your continued support and commitment!
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| Presentation |
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"PPARs and Metabolic Control"Prof. John Prins (biography)
English - 2005-03-10 - 30 minutes
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Summary :
Peroxisome Proliferator-Activated Receptors (PPARs) are ligand-dependent transcription factors that are expressed in tissues involved in energy metabolism.
The three PPAR isoforms (alpha, delta and gamma) have overlapping and complementary roles, PPAR-alpha having a predominant effect in liver and muscle, PPAR-delta in fat and muscle, and PPAR gamma in all three insulin-sensitive tissues.
Prof. Prins describes the effects of activating the PPAR isoforms, for example via their natural ligands (i.e., circulating free fatty acids and their derivatives) and synthetic ligands, including those being currently used in clinical practice or still under trial.
Overall, PPAR activation improves insulin sensitivity and tends to result in improved fuel efficiency. There may also be increases in exercise capacity and subcutaneous fat mass, a decrease in ectopic fat, and also a potential for reduced malignancies.
Copyright © 2005 E-MedHosting.com Inc.
Learning objectives :
After viewing this presentation the participant will be able to discuss:
- Metabolic effects resulting from activation of the different Peroxisome Proliferator-Activated Receptor (PPAR) isoforms;
- The clinical aspects of PPARs and their implications for diabetes and metabolic dysfunction.
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