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- December 1, 2008 |
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Welcome to the #1 online source of information for Diabetes Specialists! An international online community of more than 10,000 Diabetes Specialists.
CME on Diabetes is a website built to transmit top-level CME conferences given by international experts in endocrinology, insulin resistance, prediabetes, metabolic syndrome and type 2 diabetes. More than 2.6 million slides have been viewed since the website launch. Thank you for your continued support and commitment!
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"Relationship between hyperglycaemia and micro- and macrovascular outcomes"Prof. Timothy Davis (biography)
English - 2007-11-10 - 34 minutes
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 | (29 slides) |
Summary :
Long-term randomised controlled trials have provided good evidence for the relationship between glycaemia and the risk of vascular complications of diabetes.
The DCCT study in type 1 diabetic patients showed that intensive treatment was associated with significant improvements in microvascular outcomes. There was a low number of cardiovascular events, however fewer events were seen with intensive treatment.
Almost all the DCCT survivors joined the the epidemiological follow-up EDIC study, in which they were returned to usual care. Over time, a greater progression of albumin excretion rate was maintained in the conventionally treated patients, and in the previously intensively treated group there was maintenance of a lower rate of progression. The curves for cumulative incidence of any predefined cardiovascular outcome for the two groups separated further in the EDIC study.
In the UKPDS in type 2 diabetic patients, intensive treatment was associated with a significant 25 percent risk reduction for microvascular outcomes but a non-significant 16 percent reduction in the risk of myocardial infarction. According to post-study monitoring data that has been presented at international meetings, with an increased number of events this became a significant risk reduction.
Prof. Davis reviews the findings, discussing the absence of a glycaemic threshold for benefit, and the apparent legacy effect of good glycaemic control.
Copyright © 2007 E-MedHosting.com Inc.
Learning objectives :
After viewing this presentation the participant will be able to discuss:
- The relationship between glycaemia and vascular outcomes in type 1 and type 2 diabetes
- Evidence in support of a 'legacy' effect of good glycaemic control
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