Relationship between underlying causes of insulin resistance and beta-cell function

- December 1, 2008

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Presentation

"Relationship between underlying causes of insulin resistance and beta-cell function"

Prof. Christopher Nolan (biography)
English - 2007-11-10 - 34 minutes

(38 slides)

Summary :
Islet beta-cell failure is a key factor in type 2 diabetes pathogenesis. It is progressive, and occurs in the context of islets compensating for insulin resistance.

Beta-cell failure occurs in “susceptible” islets, and the mechanisms involved are of the initiation and progression types.

The factors that make islets susceptible to dysfunction need to be discovered, especially those that are acquired; and the mechanisms that have initiation roles in beta-cell failure. Disease modifying agents for the beta-cell in type 2 diabetes are needed.

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Learning objectives :
After viewing this presentation the participant will be able to discuss:

- GDM as an insulin resistant state
- Insulin secretion in women with previous GDM
- The influence of GDM on long-term control of glucose tolerance
- The islet beta-cell in T2DM
- Glucolipotoxicity as a proposed mechanism of beta-cell failure in T2DM

Bibliographic references :
Marc Prentki and Christopher J. NolanIslet β cell failure in type 2 diabetes J Clin Invest. 2006 July 3; 116(7): 1802–1812.

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