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- March 12, 2010 |
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"Reproductive Endocrinology" David Morris (biography)
English - 2005-08-13 - 58 minutes
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Summary :
In this talk Dr. Morris discusses the associations of underweight and overweight with with various reproductive and metabolic disorders.
In underweight, anovulation is common and this is associated with a GnRH pulse defect. Low weight is also the main risk factor for osteoporotic fracture in Canadian women, and Dr. Morris shows studies demonstrating increased risks of small for date and premature babies as well. It is therefore not advisable to induce pregnancy in underweight women.
According to the Barker Hypothesis, programming of the fetus happens under conditions of limited nutrient supply during pregnancy, preparing the baby for later starvation, but these changes promote the development of diseases later in life such as CHD and diabetes. A few cohort studies have found an increase in CVD risk with low birth weight. The Nurses' Health Study and others have also shown an increased risk of type 2 diabetes associated with low birth weight.
Dr. Morris talks about how leptin and insulin affect reproduction, and concludes with a discussion on obesity, insulin resistance and PCOS. In young women with PCOS, the risk of having type 2 diabetes has been found to go up with increasing weight. Screening these patients with glucose tolerance tests can therefore be done to detect IGT or diabetes as early as possible.
Copyright © 2006 E-MedHosting.com Inc.
Learning objectives :
After viewing this presentation the participant will be able to discuss:
- Underweight, overweight and associated reproductive disorders
- Birth weight and diabetes/vascular risk
- Reproductive effects of leptin and insulin
- Overweight and PCOS
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