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- November 20, 2008 |
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"The brain : Off limits for the insulin resistance syndrome ?"Dr. Gareth Williams (biography)
English - 2003-03-29 - 50 minutes
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 | (27 slides) |
Summary :
It is generally assumed that the brain functions largely independently of insulin. However, it has become clear that insulin can enter the brain from the circulation, and acts on defined neuronal pathways to influence important metabolic activities including food intake and sympathetic outflow to various organs. Blunting of specific central actions of insulin have been demonstrated in various animal models with resistance to peripheral actions of insulin, although the extent to which insulin influences such physiological functions in man remains uncertain. Better understanding of these neglected aspects of insulin action may help to clarify certain unexplained effects of drugs that enhance peripheral insulin sensitivity, such as the appetite-stimuling properties of thiazolidinediones.
Learning objectives :
- The action of insulin in brain-regulated metabolic activities
- The understanding of certain TZD effects linked to insulin sensitivity
Bibliographic references :
J Neuroendocrinol 2003 Jan;15(1):75-9
Cerebral insulin increases brain response to glucose.
Alquier T, Leloup C, Atef N, Fioramonti X, Lorsignol A, Penicaud L.
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