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- November 20, 2008 |
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"The Erectile-Endothelial Dysfunction Nexus: Implications for Cardiovascular Disease"Prof. Gerald Watts (biography)
English - 2006-05-06 - 35 minutes
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Summary :
In this presentation Prof. Watts talks about the association between endothelial dysfunction and erectile dysfunction.
A number of studies have shown that worsening endothelial dysfunction is predictive of cardiac events (1), and both endothelial dysfunction and erectile dysfunction have been associated with cardiovascular risk factors (2,3). Also of interest is a study published by De Angelis et al., showing that type 2 diabetic men with erectile dysfunction had clear evidence of vascular endothelial dysfunction (4). Prof. Watts discusses how conventional cardiovascular risk factors induce endothelial dysfunction, leading to erectile dysfunction.
Does erectile dysfunction predict cardiovascular disease independent of traditional cardiovascular risk factors? There is some evidence to suggest this is the case (5-7). Prof. Watts concludes with a discussion on the effects of treatment therapies for erectile dysfunction.
Copyright © 2006 E-MedHosting.com Inc.
Learning objectives :
After viewing this presentation the participant will be able to discuss:
- Endothelial dysfunction as a predictor of cardiac events
- Mechanisms of induction of endothelial dysfunction by conventional risk factors
- The association of endothelial dysfunction with cardiovascular risk factors
- The association of erectile dysfunction with cardiovascular risk factors
- Evidence for vascular endothelial dysfunction in type 2 diabetic men with erectile dysfunction
- Evidence to suggest erectile dysfunction as an independent predictor of cardiovascular disease
- Effects of treatment therapies for erectile dysfunction
Bibliographic references :
1. Volker Schächinger, MD; Martina B. Britten, MD; Andreas M. Zeiher, MDPrognostic Impact of Coronary Vasodilator Dysfunction on Adverse Long-Term Outcome of Coronary Heart Disease Circulation. 2000;101:1899.
2. Celermajer DS, Sorensen KE, Bull C, Robinson J, Deanfield JE.Endothelium-dependent dilation in the systemic arteries of asymptomatic subjects relates to coronary risk factors and their interaction. J Am Coll Cardiol. 1994 Nov 15;24(6):1468-74.
3. Virag R, Bouilly P, Frydman D."About arterial risk factors and impotence." Lancet. 1985 May 11;1(8437):1109-10.
4. L. De Angelis, M. A. Marfella, M. Siniscalchi, L. Marino, F. Nappo, F. Giugliano, D. De Lucia, D. Giugliano. Erectile and endothelial dysfunction in Type II diabetes: a possible link Diabetologia. 2001 Sep;44(9):1155-60.
5. Yavuzgil O, Altay B, Zoghi M, Gurgun C, Kayikcioglu M, Kultursay H.Endothelial function in patients with vasculogenic erectile dysfunction Int J Cardiol. 2005 Aug 3;103(1):19-26.
6. Chiurlia E, D'Amico R, Ratti C, Granata AR, Romagnoli R, Modena MG.Subclinical Coronary Artery Atherosclerosis in Patients With Erectile Dysfunction J Am Coll Cardiol. 2005 Oct 18;46(8):1503-6.
7. Carmine Gazzaruso, MD; Stefano Giordanetti, MD; Emanuela De Amici, MD; Gianandrea Bertone, MD; Colomba Falcone, MD; Diego Geroldi, MD; Pietro Fratino, MD; Sebastiano B. Solerte, MD; Adriana Garzaniti, MD. Relationship Between Erectile Dysfunction and Silent Myocardial Ischemia in Apparently Uncomplicated Type 2 Diabetic Patients Circulation. 2004;110:22-26.
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