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- November 20, 2008 |
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| Presentation |
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"The Genetics of Syndromes of Insulin Resistance"Dr. Katherine Samaras (biography)
English - 2005-06-18 - 40 minutes
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Summary :
In this presentation Dr. Samaras talks about the genetics of insulin resistance syndromes.
Abdominal fat is a key contributing factor in the metabolic syndrome, and twin and family studies show a substantial contribution of genetic factors in determining body fat mass. Genetic epidemiological studies from Dr. Samaras' group showed a gene-environment interaction in that physical activity was protective against central obesity in those with a high genetic predisposition (1). There is also evidence of multiple genes impacting on different phenotypes of the metabolic syndrome (2). Dr. Samaras discusses some of the recent molecular genetic findings in relation to the metabolic syndrome.
Drug-induced metabolic syndromes such as in the case of HAART-treated HIV-infected individuals, feature abnormalities such as mixed hyperlipidemia, insulin resistance, IGT , T2DM and peripheral fat wasting with or without central obesity. Dr. Samaras concludes by discussing the effects of rosiglitazone treatment in HIV-infected patients with lipodystrophy (3) and recently published gene expression studies in HIV adipocytes (4).
Copyright © 2005 E-MedHosting.com Inc.
Learning objectives :
After viewing this presentation the participant will be able to discuss:
- The contribution of abdominal obesity to mortality risk
- Determinants of body fat mass
- Gene-environment interactions in those predisposed to central obesity
- Genes affecting different metabolic syndrome phenotypes
- Recent findings: molecular genetic evidence in the metabolic syndrome
- Drug-induced metabolic syndromes: HIV, HAART
Bibliographic references :
1. Samaras K, Kelly PJ, Chiano MN, Spector TD, Campbell LV.Genetic and environmental influences on total-body and central abdominal fat: the effect of physical activity in female twins. Ann Intern Med. 1999 Jun 1;130(11):873-82.
2. Samaras Twin Research 2000
3. DrAndrew Carr MD, Cassy Workman MBBS, Dianne Carey MPH, Gary Rogers MBBS, Allison Martin MSc (Med), David Baker MBBS, Handan Wand PhD, Matthew Law PhD, Katherine Samaras PhD, Sean Emery PhD, ProfDavid A Cooper DSc. No effect of rosiglitazone for treatment of HIV-1 lipoatrophy: randomised, double-blind, placebo-controlled trial The Lancet.Volume 363, Issue 9407 , 7 February 2004, Pages 429-438.
4. Mallon PW, Unemori P, Sedwell R, Morey A, Rafferty M, Williams K, Chisholm D, Samaras K, Emery S, Kelleher A, Cooper DA, Carr A; SAMA Investigators.In vivo, nucleoside reverse-transcriptase inhibitors alter expression of both mitochondrial and lipid metabolism genes in the absence of depletion of mitochondrial DNA. J Infect Dis. 2005 May 15;191(10):1686-96. Epub 2005 Apr 12.
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