 |
|
 |
- November 20, 2008 |
|
|
Welcome to the #1 online source of information for Diabetes Specialists! An international online community of more than 10,000 Diabetes Specialists.
CME on Diabetes is a website built to transmit top-level CME conferences given by international experts in endocrinology, insulin resistance, prediabetes, metabolic syndrome and type 2 diabetes. More than 2.6 million slides have been viewed since the website launch. Thank you for your continued support and commitment!
|
|
|
| Presentation |
|
"The Wheres and Whats of Body Fat Distribution"Prof. Steven Kahn (biography)
English - 2003-07-14 - 37 minutes
|
 | (30 slides) |
Summary :
We have been focusing a lot lately on the roles of adipocytokines, although the distribution of body fat also plays an important part in insulin resistance. We now know that there are lean as well as obese insulin resistant patients, and about 47% of the variance in insulin sensitivity among healthy (non-diabetic) subjects can be explained by intra-abdominal fat area (Cnop M et al. Diabetes 51: 1005-15; 2002). Does central adiposity relate to an atherogenic lipid profile? Yes it does (Nieves DJ et al. Diabetes 52: 172-79; 2003). It was found that leptin levels increase with increasing subcutaneous fat and this phenomenon is more pronounced in women (Cnop M et al. Diabetes 51: 1005-15; 2002). Adiponectin levels, which are associated with insulin sensitivity, decrease with increasing intra-abdominal fat, increase with age and are higher in women than in men; also adiponectin and leptin levels are not related (Cnop M et al. Diabetologia. 46: 459-69; 2003). In this presentation we will put all these factors together – the effects of body fat distribution and adipocytokines on insulin sensitivity and NCEP ATP III criteria for the metabolic syndrome.
Learning objectives :
The participant will learn about the importance of body fat distribution in insulin resistance, and receive new information about the adipokines leptin and adiponectin in relation to body fat distribution:
- There are lean as well as obese insulin resistant patients, and about 47% of the variance in insulin sensitivity among healthy (non-diabetic) subjects can be explained by intra-abdominal fat area (Cnop M et al. Diabetes 51: 1005-15; 2002).
- Central adiposity contributes to an atherogenic lipid profile (Nieves DJ et al. Diabetes 52: 172-79; 2003).
- Leptin levels increase with increasing subcutaneous fat and this phenomenon is more pronounced in women (Cnop M et al. Diabetes 51: 1005-15; 2002).
- Adiponectin levels, which are associated with insulin sensitivity, decrease with increasing intra-abdominal fat, increase with age and are higher in women than in men; also adiponectin and leptin levels are not related (Cnop M et al. Diabetologia. 46: 459-69; 2003).
- Adiponectin levels are inversely related to triglyceride levels, and tightly correlated with HDL cholesterol levels (Cnop M et al. Diabetologia. 46: 459-69; 2003).
Bibliographic references :
Cnop M, Havel PJ, Utzschneider KM, Carr DB, Sinha MK, Boyko EJ, Retzlaff BM, Knopp RH, Brunzell JD, Kahn SE. Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex. Diabetologia. 2003 Apr;46(4):459-69.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi
Nieves DJ, Cnop M, Retzlaff B, Walden CE, Brunzell JD, Knopp RH, Kahn SE. The atherogenic lipoprotein profile associated with obesity and insulin resistance is largely attributable to intra-abdominal fat. Diabetes. 2003 Jan;52(1):172-9.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi
Cnop M, Landchild MJ, Vidal J, Havel PJ, Knowles NG, Carr DR, Wang F, Hull RL, Boyko EJ, Retzlaff BM, Walden CE, Knopp RH, Kahn SE. The concurrent accumulation of intra-abdominal and subcutaneous fat explains the association between insulin resistance and plasma leptin concentrations : distinct metabolic effects of two fat compartments. Diabetes. 2002 Apr;51(4):1005-15.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi
|
|
|
|
|
|
| Search our website |
 |
| |
Would you like to know more about insulin resistance? Are you looking for information pertaining to Type 2 Diabetes? You can find what you are looking for in over 2000 references available on CMEonDiabetes. |
| |
|
|
| Social |
|
| |
Let others know about this presentation.
|
|
|
|
