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- November 20, 2008 |
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| Presentation |
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"Thiazolidinediones and Bone - Clinical Implications"Prof. Peter R Ebeling (biography)
English - 2007-11-10 - 25 minutes
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 | (31 slides) |
Summary :
Data from observational studies suggest that diabetes is a "novel" risk factor for osteoporosis. The possible implication of insulin and molecules like TZDs in osteoporosis is getting stronger as more studies are being published.
An on-going study (1), showed that in diabetic women, the risk of fracture was increased, particularly in those receiving insulin. Dr. Ebeling presents other studies corroborating these results, including one from the Women's Health Initiative (WHI) (2). The case of TZDs is very interesting from a mechanistic point view, since there is a possibility that TZDs may act negatively on osteoblast number by increasing adipocyte differentiation (3).
As described in this presentation the dynamic between bone loss and bone formation is complex and so is the effect of diabetes and diabetes treatment on it. Clinicians will find in this presentation important information on how diabetes is being considered an osteoporosis risk factor.
Copyright © 2008 E-MedHosting.com Inc.
Learning objectives :
After viewing this presentation the participant will be able to discuss:
- Diabetes and the risk of osteoporosis; effects of insulin
- The direct and indirect effects of thiazolidinediones (TDZs, glitazones) on bone
- The mechanisms of action of this phenomenon and clinical implications
Bibliographic references :
1- Schwartz AV, Sellmeyer DE, Ensrud KE, Cauley JA, Tabor HK, Schreiner PJ, Jamal SA, Black DM, Cummings SR; Study of Osteoporotic Features Research Group.Older women with diabetes have an increased risk of fracture: a prospective study. J Clin Endocrinol Metab. 2001 Jan;86(1):32-8.
2- Bonds DE, Larson JC, Schwartz AV, Strotmeyer ES, Robbins J, Rodriguez BL, Johnson KC, Margolis KL.Risk of fracture in women with type 2 diabetes: the Women's Health Initiative Observational Study. J Clin Endocrinol Metab. 2006 Sep;91(9):3404-10.
3- Crossno JT Jr, Majka SM, Grazia T, Gill RG, Klemm DJ.Rosiglitazone promotes development of a novel adipocyte population from bone marrow-derived circulating progenitor cells. J Clin Invest. 2006 Dec;116(12):3220-8.
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