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- November 21, 2008 |
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CME on Diabetes is a website built to transmit top-level CME conferences given by international experts in endocrinology, insulin resistance, prediabetes, metabolic syndrome and type 2 diabetes. More than 2.6 million slides have been viewed since the website launch. Thank you for your continued support and commitment!
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"Treat to target"Prof. Richard O'Brien (biography)
English - 2007-04-21 - 37 minutes
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Summary :
With the current management of type 2 diabetes, a large proportion of patients are not achieving the glycaemic target. How can this be improved?
Early combination treatment may help in keeping the HbA1c down longer, says Dr. O'Brien. As seen in the United Kingdom Prospective Diabetes Study, most type 2 diabetic patients require polypharmacy to achieve long-term glycaemic control (1).
The potential advantages of early combination therapy are manifold, such as earlier achievement of therapeutic goals, reduced risk of side effects by combining drugs at lower doses, using combinations of drugs with complementary modes of action, and delaying disease progression (2). Dr. O'Brien shows data from different studies on combination therapy versus monotherapy in type 2 diabetic patients.
Copyright © 2007 E-MedHosting.com Inc.
Learning objectives :
After viewing this presentation the participant will be able to discuss:
- Why there is a need for an early and intensive approach to type 2 diabetes management
- Potential advantages of early combination therapy
- Studies illustrating greater benefit with combination therapy versus monotherapy
- Practical management considerations
Bibliographic references :
1. Robert C. Turner, FRCP; Carole A. Cull, PhD; Valeria Frighi, MD; Rury R. Holman, FRCP; for the UK Prospective Diabetes Study (UKPDS) Group. Glycemic Control With Diet, Sulfonylurea, Metformin, or Insulin in Patients With Type 2 Diabetes Mellitus: Progressive Requirement for Multiple Therapies (UKPDS 49) JAMA. 1999;281:2005-2012.
2. Del Prato S, Felton AM, Munro N, Nesto R, Zimmet P, Zinman B; Global Partnership for Effective Diabetes Management. Improving glucose management: Ten steps to get more patients with type 2 diabetes to glycaemic goal: Recommendations from the Global Partnership for Effective Diabetes Management International Journal of Clinical Practice. Volume 59 Issue 11 Page 1345-1355, November 2005.
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