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   - November 20, 2008
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 Presentation

"What are the manifestations of beta-cell dysfunction and insulin resistance?"

Dr. Steven V. Edelman (biography)
English - 2004-06-04 - 12 minutes
(3 slides)

Summary :
In the natural history of type 2 diabetes, the development of insulin resistance, impaired glucose tolerance and finally type 2 diabetes occurs over several years, with no apparent symptoms. This period is significant as insulin resistance is associated with cardiovascular abnormalities. Compensatory hyperinsulinemia maintains blood glucose levels until the point of beta cell exhaustion, when hyperglycemia becomes evident. As seen in the UKPDS, beta cell function continues to decline over time.

Copyright © 2004 E-MedHosting.com Inc.

Learning objectives :
After viewing these slides the participant will be able to discuss:

- The natural history of type 2 diabetes
- UKPDS data showing the decline in beta cell function over time

Bibliographic references :
UKPDS Group (UKPDS 16).U.K. prospective diabetes study 16. Overview of 6 years' therapy of type II diabetes: a progressive disease. U.K. Prospective Diabetes Study Group Diabetes 1995;44(11):1249-1258.

   


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